Our Services

No matter the project, we provide protein engineering and science support with the dedication and drive of an in-house team member. We work seamlessly with your team to help you achieve your goals.

We’re invested in your success and we’re in it for the long haul.

Protein Engineering

Protein engineering is a broad field of science, encompassing a variety of different techniques from random mutagenesis to rational design and protein large language model (pLLM)-based computational approaches (explore the details). Regardless of approach, the goal is the same: build a better protein by either modifying an existing protein or building a new protein with specific traits or functionality.  Essentially, protein engineering can make working with a protein easier,  enable a protein to be used in a totally new way, or create a de novo protein fit for purpose. 
Tyrala Consulting combines protein engineering expertise with a solid understanding of protein structure-function and practical application.  We match our design approach to the task at hand, taking into account your science, objectives, and downstream application. Our goal is to build you the best protein for the job. Below are examples of past projects to illustrate our capabilities. Please reach out to discuss the specifics of your project and we'll provide a plan tailored to your request.

Proteins we’ve worked on:

  • Antibodies: mAb, Fab, scFv, nanobodies,        multispecifics, ADCs, radiotherapeutics
  • Membrane proteins and surface receptors (lipid-anchored, transmembrane, peripheral)
  • Enzymes
  • Cytokines
  • DNA-binding proteins
  • Disordered proteins
  • Chimeras and fusion proteins

Example Engineering Projects:

  • Antibody engineering: reformatting, liability mitigation, conjugation site selection 
  • Antigen and small molecule target protein design
  • Design of multi-domain proteins such as chimeric antigen receptors or multi-specific engagers
  • Alter binding affinity or activity: loss/gain-of-function, enhanced function, or introduction of novel function
  • Increase catalytic turnover for an enzyme
  • Improve solubility and stability
  • Library generation for large scale screens

Let’s discuss your project specifics!